Dapoxetine under the brand name Priligy is intended for treating premature ejaculation problem in men. Premature ejaculation (PE) is a male sexual dysfunction in which a man reaches his climax quickly and too early even before his partner achieves orgasm in more than 50 percent of their sexual intercourses. Some researchers also define PE as the inability of a man to recognize that he is about to ejaculate and hence, it is beyond his control. If we’ll go by the statistics, then at least 35% of all males suffer from this sexual ailment by ejaculating within 2 minutes of penetration.
Priligy (Dapoxetine) is the only drug approved by regulatory bodies for such treatment. This short-acting SSRI (Selective Serotonin Reuptake Inhibitor) drug is already in use in a number of European countries like Sweden, Portugal, Finland, and Austria. Dapoxetine is under consideration for approval in rest of the European countries and also in the United States where it is presently lying in Phase III of the Food and Drug Administration (FDA) approval process.
Priligy (Dapoxetine) has been found to be beneficial in the treatment of premature ejaculation. According to a report published in the British Journal of Urology on the basis of data from the phase III trial, authors come to a conclusion that Dapoxetine is well-tolerated and enhance almost all variables linked to premature ejaculation that include decrease in personal misery, interpersonal difficultness, and improvement in pleasure from sexual encounters.
The arrival of Priligy (Dapoxetine) further boosts the ever-growing drug market related to male sexual health. The marketplace is already filled with erectile dysfunction drugs like Viagra (Sildenafil), Cialis (Tadalafil), and Levitra (Vardenafil), and some other dopamine agonists such as Dostinex (Cabergoline) and Pramipexole. However, all these drugs are being misused in several instances as aphrodisiacs or sexual enhancers. Healthcare providers are being coerced to prescribe Dapoxetine and other male sexual drugs off-label in people who are sexually active and don’t need the support of these drugs.
Dapoxetine was originally created and developed by Eli Lilly and Company as an anti-depressant. The credit for the invention of this drug goes to bio-chemist David T. Wong. In December 2003, Eli Lilly sold the patent of Dapoxetine to Johnson & Johnson for $65 million dollars and future royalties. The drug was submitted to FDA by ALZA Corporation and its parent company, Johnson & Johnson, in December 2004 for premature ejaculation treatment with a New Drug Application (NDA). However, FDA deferred approval of Dapoxetine in the United States by issuing the company a “not approvable” letter in October 2005. Though two further clinical trials were done in 2006, the medication is yet to get the nod from the concerned authority.
The situation in Europe is completely different. Priligy (Dapoxetine) got its first approval in February 2009 for the treatment of premature ejaculation in Sweden and Finland. Later, Portugal, Austria, and recently Italy, Germany and Spain joined that list. It is expected that other European countries will soon give their consent for the medication.
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